“龙角散”最早是江户时期秋田藩主・佐竹家的御用家传药，由藩御医藤井玄渊发明。因当时的药方中含龙骨*、龙脑和鹿角霜*且为散剂，故此得名。
藤井家族代代都是藩御医。第二代传人藤井玄信学习过兰学（西洋科学技术）后，将药方中加入了西洋草本。明治初期，第三代名医藤井正亭治为了治疗藩主的哮喘，将龙角散改良为治疗哮喘的处方，奠定了现今龙角散处方的基础。

"Ryukakusan" was originally a family medicine passed down to the family of the Satake family, the lord of the Akita domain during the Edo period, and was invented by the domain doctor, Genbuchi Fujii. It was named after the medicine at that time contained keel*, borneol and antler cream* and was in powder form.
The Fujii family has been the imperial physician of the domain for generations. After the second generation descendant Fujii Genshin studied orchidology (Western science and technology), he added Western herbs to the prescription. In the early Meiji period, Masatei Fujii, a third-generation famous doctor, improved Ryukakusan into a prescription for asthma in order to treat the feudal lord's asthma, which laid the foundation for today's Ryukakusan prescription.